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Compounded GLP-1s: Prices, Legality, and How to Buy Carefully
The market the shortage built and the resolution shrank — what compounded tirzepatide and semaglutide cost, where they legally stand, and the five questions that separate careful from lucky.
The prices
Verified all-in: compounded tirzepatide $215–$597/mo at 10 mg, compounded semaglutide $133–$348/mo standing — full rankings on the tirzepatide and semaglutide pages, complete field on the compounded directory.
The legal ground
Mass compounding's basis ended with the FDA shortage resolutions (effective early 2025); today's programs run on contested patient-specific 503A pathways under enforcement pressure — ~30 warning letters in February 2026, major players pivoting to brand-only, an April 2026 proposed rule squeezing 503B further. The moving picture, dated: is compounded tirzepatide legal in 2026?
The diligence
Quality now varies by pharmacy more than by program logo, so the five questions are the product: pharmacy name, 503A or 503B, state licensure, certificate of analysis, and prepaid-refund terms. Two programs answer the first unprompted (NexLife's named six-pharmacy 503A/503B network; Mochi's owned facility) — disclosure worth weighting as heavily as price.